Publications highlighting Mirimus technology:

Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys.
Li X, Chuang PY, D'Agati VD, Dai Y, Yacoub R, Fu J, Xu J, Taku O, Premsrirut PK, Holzman LB, He JC.
J Am SocNephrol. 2015 Feb 2. pii: JASN.2014040405. [Epub ahead of print]
PMID: 25644109 [PubMed - as supplied by publisher]

 

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW.
Cell. 2015 Jun 18;161(7):1539-52. doi: 10.1016/j.cell.2015.05.033.
PMID: 26091037 [PubMed - in process]

 

Inducible in vivo genome editing with CRISPR-Cas9.
Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW.
Nat Biotechnol. 2015 Apr;33(4):390-4. doi: 10.1038/nbt.3155. Epub 2015 Feb 18.
PMID: 25690852 [PubMed - in process]

 

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer.
Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR.
Elife. 2015 Apr 28;4:e06377. doi: 10.7554/eLife.06377.
PMID: 25919951 [PubMed - in process] Free PMC Article

 

Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.
Hogan MS, Parfitt DE, Zepeda-Mendoza CJ, Shen MM, Spector DL.
Cell Stem Cell. 2015 Mar 5;16(3):275-88. doi: 10.1016/j.stem.2015.02.001.
PMID: 25748933 [PubMed - in process]

 

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.
Boquoi A, Arora S, Chen T, Litwin S, Koh J, Enders GH.
Aging Cell. 2015 Feb;14(1):139-47. doi: 10.1111/acel.12279. Epub 2014 Dec 6.
PMID: 25481981 [PubMed - in process] Free PMC Article

 

Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.
Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, Overbey J, Rosales I, Bagiella E, Chen R, Ma M, Li L, Ding W, Djamali A, Saminego M, O'Connell PJ, Gallon L, Colvin R, Schroppel B, He JC, Murphy B.
J Clin Invest. 2015 Jan;125(1):208-21. doi: 10.1172/JCI76902. Epub 2014 Dec 1.
PMID: 25437874 [PubMed - indexed for MEDLINE] Free PMC Article
PTEN action in leukaemia dictated by the tissue microenvironment.
Miething C, Scuoppo C, Bosbach B, Appelmann I, Nakitandwe J, Ma J, Wu G, Lintault L, Auer M, Premsrirut PK, Teruya-Feldstein J, Hicks J, Benveniste H, Speicher MR, Downing JR, Lowe SW.
Nature. 2014 Jun 19;510(7505):402-6. doi: 10.1038/nature13239. Epub 2014 May 4.
PMID: 24805236 [PubMed - indexed for MEDLINE] Free PMC Article

 

In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Chuang PY, Xu J, Dai Y, Jia F, Mallipattu SK, Yacoub R, Gu L, Premsrirut PK, He JC.
Am J Pathol. 2014 Jul;184(7):1940-56. doi: 10.1016/j.ajpath.2014.03.016.
PMID: 24952428 [PubMed - indexed for MEDLINE] Free PMC Article

 

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.
Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.
Cell Rep. 2014 Sep 25;8(6):1919-29. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.
PMID: 25242322 [PubMed - indexed for MEDLINE] Free PMC Article

 

Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.
Dow LE, Nasr Z, Saborowski M, Ebbesen SH, Manchado E, Tasdemir N, Lee T, Pelletier J, Lowe SW.
PLoS One. 2014 Apr 17;9(4):e95236. doi: 10.1371/journal.pone.0095236. eCollection 2014.
PMID: 24743474 [PubMed - indexed for MEDLINE] Free PMC Article

 

A modular and flexible ESC-based mouse model of pancreatic cancer.
Saborowski M, Saborowski A, Morris JP 4th, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW.
Genes Dev. 2014 Jan 1;28(1):85-97. doi: 10.1101/gad.232082.113.
PMID: 24395249 [PubMed - indexed for MEDLINE] Free PMC Article

 

Stable RNA interference rules for silencing.
Fellmann C, Lowe SW.
Nat Cell Biol. 2014 Jan;16(1):10-8. doi: 10.1038/ncb2895. Review.
PMID: 24366030 [PubMed - indexed for MEDLINE] Free PMC Article

 

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.
Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW.
Cell Rep. 2014 Sep 25;8(6):1919-29. doi: 10.1016/j.celrep.2014.08.025. Epub 2014 Sep 18.
PMID: 25242322 [PubMed - indexed for MEDLINE] Free PMC Article

 

Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.
Zaiss AK, Zuber J, Chu C, Machado HB, Jiao J, Catapang AB, Ishikawa TO, Gil JS, Lowe SW, Herschman HR.
PLoS One. 2014 Jul 2;9(7):e101263. doi: 10.1371/journal.pone.0101263. eCollection 2014.
PMID: 24988319 [PubMed - indexed for MEDLINE] Free PMC Article

 

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.
Liu GJ, Cimmino L, Jude JG, Hu Y, Witkowski MT, McKenzie MD, Kartal-Kaess M, Best SA, Tuohey L, Liao Y, Shi W, Mullighan CG, Farrar MA, Nutt SL, Smyth GK, Zuber J, Dickins RA.
Genes Dev. 2014 Jun 15;28(12):1337-50. doi: 10.1101/gad.240416.114.
PMID: 24939936 [PubMed - indexed for MEDLINE] Free PMC Article
Creating transgenic shRNA mice by recombinase-mediated cassette exchange.
Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW.
Cold Spring HarbProtoc. 2013 Sep 1;2013(9):835-42. doi: 10.1101/pdb.prot077057.
PMID: 24003198 [PubMed - indexed for MEDLINE] Free PMC Article

 

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.
Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA Jr, Lowe SW, Pelletier J.
BMC PharmacolToxicol. 2013 Nov 13;14:58. doi: 10.1186/2050-6511-14-58.
PMID: 24219888 [PubMed - indexed for MEDLINE] Free PMC Article

 

An optimized microRNA backbone for effective single-copy RNAi.
Fellmann C, Hoffmann T, Sridhar V, Hopfgartner B, Muhar M, Roth M, Lai DY, Barbosa IA, Kwon JS, Guan Y, Sinha N, Zuber J.
Cell Rep. 2013 Dec 26;5(6):1704-13. doi: 10.1016/j.celrep.2013.11.020. Epub 2013 Dec 12.
PMID: 24332856 [PubMed - indexed for MEDLINE] Free Article

 

Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.
Livshits G, Lowe SW.
Cold Spring HarbProtoc. 2013 Nov 1;2013(11). pii: pdb.top069856. doi: 10.1101/pdb.top069856. Review.
PMID: 24184755 [PubMed - indexed for MEDLINE] Free PMC Article
A pipeline for the generation of shRNA transgenic mice.
Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW.
Nat Protoc. 2012 Feb 2;7(2):374-93. doi: 10.1038/nprot.2011.446.
PMID: 22301776 [PubMed - indexed for MEDLINE] Free PMC Article

 

Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis.
Lin CJ, Nasr Z, Premsrirut PK, Porco JA Jr, Hippo Y, Lowe SW, Pelletier J.
Cell Rep. 2012 Apr 19;1(4):325-33.
PMID: 22573234 [PubMed - indexed for MEDLINE] Free PMC Article

 

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.
Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ.
Proc Natl AcadSci U S A. 2012 Jan 17;109(3):869-74. doi: 10.1073/pnas.1119873109. Epub 2012 Jan 4.
PMID: 22219365 [PubMed - indexed for MEDLINE] Free PMC Article

 

A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW.
Cell. 2011 Apr 1;145(1):145-58. doi: 10.1016/j.cell.2011.03.012.
PMID: 21458673 [PubMed - indexed for MEDLINE] Free PMC Article

 

Reversible suppression of an essential gene in adult mice using transgenic RNA interference.
McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B, Lowe SW.
Proc Natl AcadSci U S A. 2011 Apr 26;108(17):7113-8. doi: 10.1073/pnas.1104097108. Epub 2011 Apr 11.
PMID: 21482754 [PubMed - indexed for MEDLINE] Free PMC Article

 

Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.
Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW.
Genes Dev. 2011 Oct 15;25(20):2125-36. doi: 10.1101/gad.17276711. Epub 2011 Oct 6.
PMID: 21979375 [PubMed - indexed for MEDLINE] Free PMC Article

 

Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW.
Mol Cell. 2011 Mar 18;41(6):733-46. doi: 10.1016/j.molcel.2011.02.008. Epub 2011 Feb 25.
PMID: 21353615 [PubMed - indexed for MEDLINE] Free PMC Article
Transgenic, inducible RNAi in megakaryocytes and platelets in mice.
Takiguchi M, James C, Josefsson EC, Carmichael CL, Premsrirut PK, Lowe SW, Hamilton JR, Huang DC, Kile BT, Dickins RA.
J ThrombHaemost. 2010 Dec;8(12):2751-6. doi: 10.1111/j.1538-7836.2010.04077.x.
PMID: 21138522 [PubMed - indexed for MEDLINE] Free PMC Article