Publications

Transgenic, inducible RNAi in megakaryocytes and platelets in mice.
Takiguchi M et al., 2010 Journal of Thrombosis and Haemostasis – 2010 December 8
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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.
Chien Y., 2011 Genes & Development – 2011 October 15
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Reversible suppression of an essential gene in adult mice using transgenic RNA interference.
McJunkin K et al., 2011 Genes & Development – 2011 October 15
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A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Premsrirut PK et al., 2011 Cell - 2011 April 1
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Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Fellmann C., 2011 Molecular Cell – 2011 March 18
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A pipeline for the generation of shRNA transgenic mice.
Dow LE et al., 2012 Nature Protocols - 2012 February 2
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Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.
Tan X et al., 2012 Proc Natl Acad Sci USA – 2012 January 17
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An optimized microRNA backbone for effective single-copy RNAi.
Fellmann C et al., 2013 Cell Reports - 2013 December 26
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Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.
Livshits G et al., 2013 Cold Spring Harbor Protocols - 2013 November 1
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Creating transgenic shRNA mice by recombinase-mediated cassette exchange.
Premsrirut PK et al., 2013 Cold Spring Harbor Protocols - 2013 September 1
Publication
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.
Nasr Z et al., 2103 Cold Spring Harbor Protocols - 2013 September 1
Publication
Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.
Bolden JE et al., 2014 Cell Reports – 2014 September 25
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In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells.
Chuang PY et al.,2014 The American Journal of Pathology - 2014 July
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Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.
Liu GJ et al., 2014 Genes & Development – 2014 July 15
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Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.
Zaiss AK et al., 2014 PLoS One – 2014 July 2
Publication
PTEN action in leukaemia dictated by the tissue microenvironment
Miething C et al., 2014 Nature - 2014 June 19
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Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.
Dow LE et al., 2014 PLoS One - 2014 April 17
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Stable RNA interference rules for silencing.
Fellmann C et al., 2014 Nature Cell Biology – 2014 January 16
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A modular and flexible ESC-based mouse model of pancreatic cancer.
Saborowski M et al., 2014 Genes & Development - 2014 January 1
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Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys.
Li X et al., 2015 J Am Soc Nephrol – 2015 Oct 26
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Cohesion loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
Mullenders JA et al.,2015 J Exp Med - 2015 Oct 19
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Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Dow LE et al., 2015 Cell - 2015 June 18
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The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer.
Wang E et al., 2015 eLIFE - 2015 April 28
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Inducible in vivo genome editing with CRISPR-Cas9.
Dow LE et al., 2015 Nat Biotechnology - 2015 April
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Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.
Hogan MS et al., 2015 Cell Stem Cell – 2015 March 5
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Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.
Boquoi A et al., 2015 Aging Cell - 2015 February
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Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.
Menon MC et al., 2015 Pubmed - 2015 January
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Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a
Strikoudis A et al.,2016 Nat Cell Biol. 2016 Nov 18
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Tumor cells survival dependence on the DHX9 DExH-box helicase
Lee T et al.,2016 Oncogene. 2016 Sep 29
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Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland
Baker L et al., 2016 Cell Sci - 2016 Jun 15
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Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
Yu Liu et al., 2016 Nature - 2016 March 16
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Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.
Saya H. Ebbesen et al., 2016 Proc Natl Acad Sci U S A – 2016 March 15
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Prediction of potent shRNAs with a sequential classification algorithm.
Raphael Pelossof et al., 2017 Nat Biotech - 2017 March 06
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Genetically engineered mouse models in oncology research and cancer medicine
Kelly Kersten et al.,2017 EMBO Mol Med – 2017 Feb 09
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